"Innistrad is a plane of menace and dread where every creature hides a darker aspect. Here, hedonistic vampires stalk the shadows to quench their thirst, and the full moon can transform a simple villager into a savage werewolf. Best to huddle inside, Planeswalker, lest the horrors of this world rend you limb from limb."
Each of the five colors has it's specific focus on an aspect of the horror theme:
- White -- Angels/Clerics
- Blue -- Ghosts/Mutants/Zombies
- Black -- Vampires/Zombies/Demons
- Red -- Vampires/Werewolves
- Green -- Werewolves/Shamans
And last not least, there are (at least) two cards in this MtG expansion that share names with cards in VtES, namely Murder of Crows and Wooden Stake.
Reference: Innistrad product page.
Post Scriptum: Yes, I am a little envious of the money WotC is able to spend on the artwork for the Magic cards (in contrast to most VtES cards).